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Rakesh K. Tyagi

Rakesh K. Tyagi

Rakesh K. Tyagi
Rakesh K. Tyagi
Professor
Centre/School/Special Centre
Special Centre for Molecular Medicine
Room No
3B (GF)
Off. Phone
011-26738741
Email
rkt2300@mail.jnu.ac.in, rktyagi@yahoo.com
Personal Webpage
https://jnu.ac.in/Faculty/rtyagi
Qualifications

PhD

Areas of Interest/Specialization

Molecular and Cellular Endocrinology / Nuclear Receptors in Health and Disease

Experience

Research 37 years; Teaching 22 years

Awards & Honours
  1. Awarded Feinberg fellowship of The Weizmann Institute of Science, Israel, 1993-1995.
  2. Awarded INSERM International Fellowship, France, 1995-1997.
  3. Awarded French Medical Research Fellowship by ‘Foundation pour la Recherche Medicale’ 1997-1998.
  4. NIH Visiting Research Fellowship at the University of Texas Health Science Center (UTHSCSA)
  5. Awarded FRE (Fellow in Reproduction and Endocrinology) by Society of Reproductive Biology and Comparative Endocrinology, 2009.
  6. Gold medal oration award by the Society of Reproductive Biology and Comparative Endocrinology (SRBCE) for significant contribution in the area of Molecular and Cellular Endocrinology, 2011.
  7. Editor-in-Chief of the ‘Journal of Endocrinology and Reproduction’ 2023 onwards.
International Collaboration/Consultancy

None

Best Peer Reviewed Publications

Google Scholar profile of RK Tyagi

 

  1. Rizvi S, Chhabra A, Tripathi A, Tyagi RK (2023) Mitotic genome-bookmarking by nuclear hormone receptors: A novel dimension in epigenetic reprogramming and disease assessment. Molecular Cellular  Endocrinology. 18:112069. doi: 10.1016/j.mce.2023.112069 (in Press)
  2. Kashyap J, Kumari N, Ponnusamy K, Tyagi RK (2023) Hereditary Vitamin D-Resistant Rickets (HVDRR) associated SNP variants of vitamin D receptor exhibit malfunctioning at multiple levels. BBA-Gene Regulatory Mechanisms Volume 1866: 194891 (impact factor 2022 6.3)
  3. Thakur K, Emmagouni Sharath Kumar Goud, Jawa Y, Keswani C, Onteru S, Singh D, Singh SP, Roy P, Tyagi RK (2023) Detection of endocrine and metabolism disrupting xenobiotics in milk-derived fat samples by fluorescent protein-tagged nuclear receptors and live cell imaging. Toxicology Mechanisms and Methods  33:293-306.
  4. Kashyap J, Tyagi RK (2022) Mitotic genome bookmarking by nuclear receptor VDR advocates transmission of cellular transcriptional memory to progeny cells (2022) Experimental Cell Research 417:113193
  5. Saha P, Kumar S, Datta K and Tyagi RK (2021) Incidence of increased autophagy in mifepristone treated in vitro and in vivo polycystic ovarian models and its reversion upon thymoquinone treatment. Journal of Steroid Biochemistry and Molecular Biology. 208:105823
  6. Kumar S, Vijayan S, Dash AK, Gourinath S and Tyagi RK (2021) Nuclear Receptor SHP Dampens Transcription Function and Abrogates Mitotic Chromatin Association of PXR and ERα via Intermolecular Interactions. BBA-Gene Regulatory Mechanisms 1864:194683.
  7. Singh SK, Yende AS, Ponnusamy K and Tyagi RK (2019) A comprehensive evaluation of anti-diabetic drugs on nuclear receptor PXR platform Toxicol In Vitro 60: 347-358.
  8. Rana M, Dash AK, Ponnusamy K and Tyagi RK (2018) Nuclear localization signal region in nuclear receptor PXR governs the receptor association with mitotic chromatin. Chromosome Research 26: 255-276.
  9. Dash AK, Yende AS, Jaiswal B, Tyagi RK (2017) Heterodimerization of Retinoid X Receptor with Xenobiotic Receptor partners occurs in the cytoplasmic compartment: mechanistic insights of events in living cells. Experimental Cell Research 360:337-346.
  10. Rana M, Devi S, Gourinath S, Goswami R, Tyagi RK (2016) A comprehensive analysis and functional characterization of naturally occurring non-synonymous variants of nuclear receptor PXR. Biochimica et Biophysica Acta – Gene Regulatory Mechanisms 1859: 1183–1197.


Total Published Research Articles in National/International Journals: 80

Total Published Abstracts in National/International Journals: ~50

Recent Peer Reviewed Journals/Books

Biochemical Pharmacology, PLoS one, FEBS Journal, Xenobiotica, Journal of Endocrinology and Reproduction, Biochimca Biophysica Acta (BBA), Nature Methods, etc.

Patents (if any)

Tyagi RK, Negi S, Kumari S, Saradhi M and Mukhopadhyay G. Stable integration of a xenobiotic receptor promoter-reporter DNA construct into a human liver cell line for evaluating the drugs by high throughput screening. Indian Patent filed through IPM cell at JNU, New Delhi. 

Indian Patent Application. No. 464/DEL/2010. 
International (PCT) patent application number PCT/IN2011/000127 filed on 01.03.2011.
Publication no.: WO/2011/108003

The present claim relates to generation of a liver cell line that is stably integrated with a promoter-reporter DNA construct and has utility in analyzing those prescription drugs, herbal drug ingredients and other xenobiotics/factors that have modulatory effects on cellular levels of PXR protein i.e. up regulation or down regulation of PXR. 

Executive Summary UGC project F.No.41-1294-2012(SR)

A warm welcome to the modified and updated website of the Centre for East Asian Studies. The East Asian region has been at the forefront of several path-breaking changes since 1970s beginning with the redefining the development architecture with its State-led development model besides emerging as a major region in the global politics and a key hub of the sophisticated technologies. The Centre is one of the thirteen Centres of the School of International Studies, Jawaharlal Nehru University, New Delhi that provides a holistic understanding of the region.

Initially, established as a Centre for Chinese and Japanese Studies, it subsequently grew to include Korean Studies as well. At present there are eight faculty members in the Centre. Several distinguished faculty who have now retired include the late Prof. Gargi Dutt, Prof. P.A.N. Murthy, Prof. G.P. Deshpande, Dr. Nranarayan Das, Prof. R.R. Krishnan and Prof. K.V. Kesavan. Besides, Dr. Madhu Bhalla served at the Centre in Chinese Studies Programme during 1994-2006. In addition, Ms. Kamlesh Jain and Dr. M. M. Kunju served the Centre as the Documentation Officers in Chinese and Japanese Studies respectively.

The academic curriculum covers both modern and contemporary facets of East Asia as each scholar specializes in an area of his/her interest in the region. The integrated course involves two semesters of classes at the M. Phil programme and a dissertation for the M. Phil and a thesis for Ph. D programme respectively. The central objective is to impart an interdisciplinary knowledge and understanding of history, foreign policy, government and politics, society and culture and political economy of the respective areas. Students can explore new and emerging themes such as East Asian regionalism, the evolving East Asian Community, the rise of China, resurgence of Japan and the prospects for reunification of the Korean peninsula. Additionally, the Centre lays great emphasis on the building of language skills. The background of scholars includes mostly from the social science disciplines; History, Political Science, Economics, Sociology, International Relations and language.

Several students of the centre have been recipients of prestigious research fellowships awarded by Japan Foundation, Mombusho (Ministry of Education, Government of Japan), Saburo Okita Memorial Fellowship, Nippon Foundation, Korea Foundation, Nehru Memorial Fellowship, and Fellowship from the Chinese and Taiwanese Governments. Besides, students from Japan receive fellowship from the Indian Council of Cultural Relations.